Sadly, by 1939, most of the distinguished doctors and scientists photographed honoring Rife at the estate of Dr. Milbank Johnson, denied that they ever met Rife! This was due to medical politics and pressure from the pharmaceutical industry, to put it mildly. Historically, medical visionaries have been persecuted and ridiculed for challenging the orthodox medical views of their day. For example, Louis Pasteur was criticized for years for his theory that germs could cause disease, Morton for promoting the "absurd" idea of anesthesia and Harvey for his theory of the circulation of blood.

First, arsonists burned the Burnett Lab in New Jersey, which was validating Rife's work. Later, on the eve of a press conference to announce the results of the 1934 study, Dr. Milbank Johnson, former president of the southern California AMA, was fatally poisoned and his papers "lost".

Also, after a failed attempt by Morris Fishbein to buy the rights to Rife's machine for the medical drug industry, Rife's labs were destroyed by arson and sabotage. Dr. Nemes, who had duplicated some of the work of Rife, was killed in a mysterious fire that destroyed all his research papers. These and other incidents lead Rife to stop his research.

It took many years for Rife's colleagues to secretly reconstruct enough of his burned and stolen research work to make effective Rife instruments again available to the public.

In 1950 a man by the name of John Crane met Roy Rife. Their partnership resulted in the further development and improvement of Rife's microscope and frequency instruments. By 1954, Rife's description of the cancer cure was copyrighted under Crane's urging. However, neither had the resources that were available to Rife in the 1930's. So, building a high-powered Ray Tube was impossible. Crane believed that a much smaller Frequency Instrument that attached to the body could be just as supportive. This direct method in fact was shown to be useful and more convenient. By 1960, Crane wrote and copyrighted a manual explaining how this Frequency Instrument was to be used.

Inevitably, John Crane faced the same opposition and persecution that Royal Rife did in trying to bring a cure for cancer to the general public. Although Crane lacked the skills needed to bring Rife's discoveries and inventions into mainstream acceptance and utilization, he enabled the Rife story to be told. (For a more in-depth discussion, you can refer to the book 'The Cancer Cure That Worked!' written by Barry Lynes.)